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doi: 10.1097/GME.0000000000001143 8 Lovejoy JC, Champagne CM, de Jonge L, Xie H, Smith SR

Participants Participant 1 is a 51-year-old woman with severe treatment-resistant obesity (body mass index (BMI) = 46.5 kg m 2 ) and distressing food preoccupation despite bariatric surgery

Specific amino acid substitutions and a C18 fatty-acid side chain enhance albumin binding, reduce renal elimination, and confer resistance to DPP-4 degradation, extending its half-life to approximately one week and enabling once-weekly administration [14]

The article ties access to provincial health insurance formularies, private coverage and individual clinical criteria rather than one national rule

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This clinical study involved 24 obese male patients undergoing gastric sleeve surgery, also called sleeve gastrectomy, at Stanford Hospital