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In a clinical study involving patients with refractory SLEdefined as those with persistent disease activity despite high-dose glucocorticoids and/or cytotoxic drugsthe combination of Low-dose IL-2 (100 WIU, 35 days/month) and rapamycin(0.5 mg every other day) demonstrated synergistic effects (272)

Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

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Notably, Formononetin treatment significantly impeded the proliferation capacity of breast cancer cells, as evidenced by the inhibition of colony formation observed in clone formation assays

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