Ruman (Diagen) in 1993 using a solid phase synthesis 12 , a method which is based on the classic Merrifield synthesis 13 , where peptide is synthesized stepwise on a modified solid polystyrene support (resin)
one that binds too loosely offers no advantage over a free ion and can catalyze damaging redox reactions
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Hu C, Gao S, Li X, Yang K, Cheng Y, Guo W et al (2025) Crosstalk of autophagy and ferroptosis in cardiovascular diseases: from pathophysiology to novel therapy
doi: 10.1016/j.ijrobp.2018.02.175 179 DiaoKBianSXRoutmanDMYuCYeJCWagleNAet al
For example, matrix metalloproteinase (MMP)-sensitive peptides or phospholipids containing cleavable ester or amide linkages may be included in the liposomal bilayer