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During weight loss, the body is at risk of breaking down muscle tissue for energy especially when food intake drops significantly

Ferreira JP, Butler J, Rossignol P, Pitt B, Anker SD, Kosiborod M, et al

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9 Further evidence for the physiological role of GLP-1 in regulating GCG secretion accrued from studies showing that exendin (939), an antagonist of the GLP-1 receptor, impairs oral glucose tolerance 10 by disinhibiting GCG secretion when blood glucose concentration is normal or elevated