Supplementary material The Supplementary Material for this article can be found online at: Glossary HPO hypothalamic-pituitary-ovarian GnRH gonadotropin-releasing hormone THRs thyroid hormone receptors TSH thyroid-stimulating hormone fT3 free triiodothyronine fT4 free thyroxine FSH follicle-stimulating hormone LH luteinizing hormone E2 estradiol P progesterone PRL prolactin PrF primordial follicles PF primary follicles SF secondary follicles AF antral follicles CL corpora lutea AtF atretic follicles PMSG pregnant mare serum gonadotropin hCG human chorionic gonadotropin COCs cumulus-oocyte complexes PCOS polycystic ovarian syndrome DOR diminished ovarian reserve DEGs Differentially expressed genes GO Gene ontology MMI methimazole TUNEL Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling Gpx4 Glutathione Peroxidase 4 Slc7a11 Solute Carrier Family 7 Member 11 Acsl4 Acyl-CoA Synthetase Long Chain Family Member 4 Lpcat3 Lysophosphatidylcholine Acyltransferase 3 Aifm2 Apoptosis Inducing Factor Mitochondria Associated 2 Gch1 GTP Cyclohydrolase 1 Casp1 pyroptosis-related genes, including Caspase 1 Casp11 Caspase 11 Gsdmd Gasdermin D Gsdme Gasdermin E Bcl2 BCL2 Apoptosis Regulator Bcl2l1 BCL2 Like 1 Bad BCL2 Associated Agonist Of Cell Death Casp3 Caspase 3 Casp9 Caspase 9 References 1 BrownE
One of the most significant of these is the activation of SIRT1, often called a longevity gene. SIRT1 helps manage insulin sensitivity and supports healthier blood sugar regulation, which is fundamental for sustained energy and preventing the metabolic strain that can lead to weight gain
Immune-related toxicities are autoimmune conditions that can affect any organ in the body after ICI administration, with natural histories that are distinct from their de novo autoimmune disease counterparts
For 2.5 mg dose, draw 100 units (1ml) on insulin syringe
If no preservative, use immediately or within 24 hours if refrigerated, unless specified.14 Precautions: Do not freeze
doi: 10.1021/acs.jproteome.1c00341 281 MrklSButlerMIHollACryanJFDinanTG
