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Studies have shown that GLP-1RA affects the key phases by reducing its main cytokines and chemokines, such as TNF, IL-6, IL-10, and IL-12, and MCP-1, leading to a reduced inflammatory state, improved endothelial function, and promoted cholesterol efflux
1B, Supplementary Fig
They mimic GLP-1s activity but resist degradation, allowing them to remain active in the body for longer
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In all, participants who received tirzepatide lost an additional 18.4% of their body weight compared to a weight gain of 2.5% in the placebo group