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In the Cagrilintide groups, observed mean weight losses ranged from 5.0% to 9.8% at week 32, slightly less than the 6.1% to 10.8% observed at week 26

Reduction in the activity of this enzyme decreases the conversion of substrates into fatty acids, thereby shifting cellular metabolism toward lipid mobilization rather than storage [1]

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Genetic mouse models deficient in other TAG lipases will also be needed to determine their relative contribution to lipolysis