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In other cells, various signaling cascades, including activation of MAPK, phospho-inositol-3-phosphate kinase (PI3K), adenylate cyclase and PKC by GLP-1 agonists, mediate the effects of GLP-1R activation on various cellular functions including insulin secretion and biosynthesis, -cell proliferation and neogenesis

Studies studying the mechanisms underlying IGF1 LR3s effects on muscle have revealed its dual action on hypertrophy and hyperplasia

IGF-1 induced activation of IGF-1R led to AKT (Protein Kinase B) phosphorylation that may phosphorylate BAD (BCL2 Associated Death Promoter) and its dissociation from BCL2 to prevent apoptosis

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Pehar M, Vargas MR, Robinson KM, Cassina P, Diaz-Amarilla PJ, Hagen TM, et al

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