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This cytokine is produced by activated macrophages as a proprotein which is proteolytically processed to its active form by caspase 1 (CASP1/interleukin-1-converting enzyme)

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial. GLP-1 and obesity: International Journal of Molecular Sciences (2019)

First, exenatide crosses well and still fails in the Phase 3 Exenatide-PD3 trial, so brain access cannot be the whole story

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If confirmed, they may help explain the therapeutic effects that psychedelics can have on anxiety, depression and addiction, researchers said