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Glucose-stimulated insulin secretion in islets isolated from n = 10 male 18-wk old C57BL6/J mice (Run 1) and n = 10 female 12-wk old C57BL/6 J mice (Run 2), and which were treated with either control, GLP-1RA, GLP-1/Tesaglitazar or GLP-1RA + Tesaglitazar (n = 6/6/6/5 biologically independent replicates) under dynamic drug concentrations up to 3 nM under glucose concentrations of 10 mM (c,d)

RR, Risk Ratio

Glucosedependent insulinotropic polypeptide activates the RafMek1/2ERK1/2 module via a cyclic AMP/cAMPdependent protein kinase/Rap1mediated pathway

2020;43(Suppl 1):S98110

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