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However, in rodents, in 95.83% of the cases, supplementation with a large variety of polyphenols during and after PRS and POS mostly ameliorates ES-induced changes in behavior across the various domains

While these symptoms are typically most pronounced during initial treatment and dose increases, they often improve with time as the body adapts

Prior phase 2 work in MASH (F1-F3) with lower-dose semaglutide demonstrated substantial MASH resolution but a more modest impact on fibrosis, suggesting that fibrosis regression may lag or be less tightly coupled to early weight loss [8]

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Parvanova A, et al

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