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Ethics declarations Ethics and consent to participate The animal research procedures were approved by The First Peoples Hospital of Lianyung, lianyungang (Ethics approval number: : IACUC20250611 (R11) and carried out in accordance with the Guide for the Care and Use of Laboratory Animals (Ministry of Science and Technology of China, 2006)

Dysregulated NLRP3 expression can disrupt immune homeostasis and is associated with various auto-inflammatory disorders (250)

The post-translational modifications of GPX4 mainly include succination, ubiquitination and alkylation

The No-DAC version more closely mimics natural pulsatile GH release patterns and is generally preferred for this reason

Potential mechanisms promoting increased hepatic de novo serine synthesis from glucose Work by independent groups indicate that SAAs negatively regulate serine synthesis

MLKL, mixed lineage kinase domain-like