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Gastrointestinal Reactions (Reported/Theoretical) : Some reports suggest possible nausea or digestive discomfort, although consistent human data are lacking

Lancet 377:19291937 Creager MA, Olin JW, Belch JJ, Moneta GL, Henry TD, Rajagopalan S, Annex BH, Hiatt WR (2011) Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication

Always use gentle swirling motions instead

Side effects are rare and typically limited to mild local irritation at the injection site

These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks

Let them dry