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To investigate whether the increased GSH level at 100 g/ml 5-FOA (Figure S2A) was stable during longer-term cultivation of the modified strain, cellular GSH content was monitored every 10 generations during sequential batch cultivation in flasks at 100 g/ml 5-FOA (after every ~ 10 generations, aliquots of overnight culture were transferred to fresh medium giving OD 0.01 and re-incubated)

Its pathogenesis is largely explained by two main axes: skin barrier defects and immune dysregulation (Weidinger and Novak 2016

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Drug Dev Ind Pharm , 2011, 37(11): 1282-1289

Arango, V

Liu, M., Svirskis, D., Proft, T., Loh, J., Yin, N., Li, H., et al