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doi: 10.3389/fnut.2024.1422431 Received 24 April 2024 Accepted 08 August 2024 Published 23 August 2024 Volume 11 - 2024 Edited by Michael Mathai, Victoria University, Australia Reviewed by Mario Perello, National Scientific and Technical Research Council (CONICET), Argentina Maedeh Ghasemi, Isfahan University of Medical Sciences, Iran Updates Copyright 2024 Ma, Yan, Wang, Guo and Yu

For most participants in clinical trials, diarrhoea is most pronounced during the dose-escalation phase of treatment