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A meta-analysis of 77 RCTs involving 50,820 patients with T2DM found that compared with placebo, lifestyle modification, or active anti-diabetic drugs, SGLT2is were associated with a significantly higher risk of genital infections (RR, 3.30

For a temperature-sensitive medication like semaglutide, shipping delays raise storage and stability concerns

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The SURMOUNT trials for weight management similarly showed infrequent pancreatitis cases, with rates not significantly elevated compared to placebo

In conjunction, these studies underscore that the inhibition of aspartate and asparagine metabolism, or their deprivation, might be a compelling therapeutic strategy against some tumors

This suggests as many as one in 1,000 GLP-1 RA users could progress to new age-related macular degenaration over unexposed patients: if this risk was carried over millions of users, those affected could end up being a sizable group of patients, he said