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10.3389/fphar.2021.755600 Front

However, the impact of GSH across all the tissues in adult animals is unknown because mice that lack GCLC undergo an early embryonic lethality 14,15,16

doi:10.1002/dta.233 (source) Alba M, Fintini D, Sagazio A, et al

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It disrupts the structural integrity of cell membranes, but due to the incidence of hepatotoxicity, the drug was eliminated from clinical trials [151]

Kallifatidis G, Rausch V, Baumann B, Apel A, Beckermann BM, Groth A, et al