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Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6

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PMCID: PMC4141528 ) Aster RH, Curtis BR, McFarland JG, Bougie DW (2009) Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management

Unele studii arat c suplimentarea cu L-carnitin poate crete sensibilitatea la insulin la diabetici prin reducerea nivelului grsimilor din muchi

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Group II received a single oral dose of 150 mg/kg of APAP and a dose of GSH 200 mg/kg (mouse dose according to Wendel and Jaeschke (1982)) solubilized in 100 ml of physiological saline solution by intravenous infusion