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While the supplement successfully and dramatically improved the patients' blood inflammatory markers (lowering the pro-inflammatory AA:EPA ratio), it did not result in statistically significant improvements in clinical symptoms like fatigue or shortness of breath

IL-1, IL-6, IL-17, and TNF- are also elevated in the postmortem brains of ASD patients [319, 320]

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This impact is higher than prior estimates due to the incorporation of actual experience so far in 2025, which is significantly higher than estimated

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These biomarkers inform whether semaglutide is appropriate, what starting dose makes sense, and whether dose escalation is safe based on individual tolerability