de Kretser DM, Loveland KL, Meinhardt A, Simorangkir D, Wreford N
Weight loss can change body proportions, which might make some people perceive differences but that doesnt mean the drug causes physical enlargement
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Wegovy (semaglutide 2.4mg) achieved average 15% body weight loss over 68 weeks in pivotal trials, while Zepbound (tirzepatide 15mg) demonstrated average 20.9% body weight loss over 72 weeks
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Critical limitations include: Heterogeneity : Different strains, doses, and formulations make comparisons difficult Small effect sizes : Weight changes are typically modest and may not be clinically significant Short duration : Most studies last 12 weeks or less, providing no data on sustained effects Publication bias : Negative studies may be underreported There is no high-quality evidence that probiotic supplements can replicate the substantial weight loss achieved with prescription medications like semaglutide or tirzepatide
