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When this stress becomes significant, it can cause degenerative spondylolisthesis (anterior displacement of a vertebral segment) with or without spondylolysis (defect in the pars interarticularis), which can contribute to lumbar spinal stenosis

Getting the wrong diagnosis means using treatments that either do nothing or make things worse

Frontiers in Drug Delivery 2, 957732 (2022)

Altered circulating concentrations of active glucagon-like peptide (GLP-1) and dipeptidyl peptidase 4 (DPP4) in obese subjects and their association with insulin resistance

Adequate iron chelation therapy for at least six months improves survival in transfusion-dependent patients with lower risk myelodysplastic syndromes

Lower doses are typically used initially to assess tolerance and effectiveness