A 2024 study published in JAMA Ophthalmology found that semaglutide users faced a higher risk of developing NAION when treated for diabetes or obesity
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In STEP 5 (NCT03693430), semaglutide (2.4 mg/week subcutaneously) resulted in sustained weight loss for 2 years versus placebo in people with overweight/obesity without diabetes (15.2% versus 2.6%) [71]
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miRNA-mediated and epigenetic regulatory mechanisms GLP-1RAs participate in the epigenetic regulation of the processes of tumorigenesis and cancer progression by modulating gene expression and changes in DNA methylation
Experts still don't know why GLP-1 users report taste changes, according to Steven Munger, professor at the University of Virginia