PubMed Rosenstock J, et al
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From that point, degradation begins, slowly at first but accelerating over time
Distribution of score severity (12, 1318 or 19) was also similar with 6, 12 and 5 subjects in the ARA 290 group and 4, 13 and 6 subjects in the placebo group, respectively
It's a catastrophic, yet entirely avoidable, scenario