Our findings, which utilize a novel CSMN reporter line with TDP-43 pathology, not only reveal the presence of metabolomic defects at an early stage of the disease, but also suggest that proper modulation of metabolomic imbalance could offer therapeutic strategies to improve the integrity of mitochondria, and thus the health of diseased UMNs
doi: 10.3389/fimmu.2024.1404615 125 KavehKFuF
A: It should be used during pregnancy only if prescribed by a doctor
To determine whether there might be a relationship between weight loss medication use immediately before or during pregnancy and various maternal and neonatal outcomes, we compared the rates of preterm delivery, high birth weight, neonatal intensive care unit (NICU) admission, and diagnoses of failure to thrive or congenital heart defect for babies born to mothers prescribed phentermine or a GLP-1 medication in the 90 days before pregnancy or during the first trimester to those with no documented weight loss medication exposure during pregnancy
J Cereb Blood Flow Metab 40:17691777
The studies that looked at subjective sleep quality using different rating scales found no significant overall improvement in adults taking melatonin compared to a placebo (Choi et al., 2022)
