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Risk of High Potassium (Hyperkalemia) Avoid combining with kidney disease[4] medications such as: Spironolactone (Aldactone, Carospir) Amiloride (Midamor) Triamterene (Dyrenium) Why: Both L-arginine and these chronic kidney disease medications can increase potassium levels in the blood

Interestingly, GIPR agonists alone do not typically result in weight loss

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Orforglipron is not yet approved by the FDA, but adults with obesity and Type 2 diabetes who took the highest dose of the pill for 72 weeks in a late-stage trial lost an average of 23 pounds, or 10.5% of their body weight, Eli Lilly announced