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Funding This work was supported by the National Natural Science Foundation of China (31870906, 81974254, 82170470, and 82270903), Hubei Provincial Natural Science Foundation (2022CFB453), Foundation of Health Commission of Hubei (WJ2021M061, WJ2019F071), the Natural Science Foundation of the Bureau of Science and Technology of Shiyan City (grant no

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Intriguingly, a blockade of central estrogen receptors reduces the effect of a GLP-1R analog (exendin-4) on food-motivated behavior in both sexes, indicating that estrogen may modulate the effects of GLP-1 analogs not only in females but also in males (40)

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