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Adjusting the dose, switching peptides, or stopping treatment are valid responses based on clinical judgment

This can be justified by studies showing high metabolic activity in the cerebellar nuclei in Lurcher mice, which could lead to high oxygen free radical and neurons death due to toxicity in older Lurcher mice [137, 154]

b) supplementation at least for 12 weeks

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GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone involved in appetite control and insulin response

In Part B, drug safety and the change in fructosamine levels from baseline were evaluated as secondary objectives