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Approximately 70% of RA patients are ACPA-positive, correlating with severe disease (13)

Importantly, with the advent of more potent GLP-1 receptor agonists like semaglutide, it is crucial to study these newer medications individually rather than grouping them with older drugs in the same class, as their effects may differ significantly, she added

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GLP-1R signaling regulates brain energy homeostasis and may improve mitochondrial function in depression In addition to the disturbed neuroimmune and neuroendocrine crosstalk, disruptions in brain metabolism and mitochondrial functions seem to be an emergent field of interest in the context of depression pathogenesis

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The smartest approach is to start with realistic expectations