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WEIGHT GAIN In the UKPDS, sulfonylurea treatment caused a net weight gain of approximately 3 kg, which occurred during the first 3-4 years of treatment and then stabilized (21,34)

The extended absorption phase contributes to the sustained therapeutic effect throughout the dosing interval

In addition, prolactin testing is also reasonable in certain specific clinical situations, such as (i) when standard weight loss and metabolic interventions fail to achieve the expected clinical or biochemical improvement

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