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Combined with the return of baseline appetite signals, this creates a biological environment where overeating becomes much easier
Since nicotinamide nucleotide transhydrogenase (NNT), which is functional in C57BL/6N mice but not in C57BL/6J mice (Freeman et al., 2006), oxidizes mitochondrial matrix NADH to NAD + , the increased longevity of the C57BL/6J strain may be due in part to the reduction of the mitochondrial matrix [NAD + ]/[NADH]
This selective reduction occurs because GLP-1 signaling improves insulin sensitivity in your liver and metabolic organs, reducing the drive to store internal belly fat
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