Besides its role in regulating cell division, viability, and motility, compressive forces can also influence gene expression [123]
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In aged rat models, treatment increased activity of antioxidant enzymes like superoxide dismutase (SOD), glutathione peroxidase, and glutathione-S-transferase, improving overall oxidative defense
Calcium and vitamin D intake, along with regular exercise, can help mitigate this risk
Supplemental lipoic acid also decreased the serum concentrations of some (IFN-, ICAM-1, TGF-, IL-4), but not all markers (TNF-, IL-6, MMP-9), cytokines and other inflammation (98)