Chronic low-grade inflammation accompanying these conditions is mediated by activation of several molecular pathways, notably NF-B, MMP-9 (matrix metalloproteinase-9), MAPKs (mitogen-activated protein kinases), COX-2 (cyclo-oxygenase-2), and STAT-3 (signal transducer and activator of transcription-3)
Materials and methods Animals Sixty SPF-grade healthy female SD rats, aged 68 weeks, weighing 200220 g, were purchased from Heyuan Biotechnology (Shanghai) Co., Ltd
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