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Unpublished studies have also demonstrated that the IGF-1Rs of PPP treated cells are undergoing rapid downregulation

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This leads to increased production and transfer of melanosomes to keratinocytes, with inflammatory mediators like leukotrienes and prostaglandins further exacerbating the condition 129

J Hum Nutr Diet 2002;15:14556

Rarer issues include vein inflammation (phlebitis), infection, allergic reactions and, in people with heart or kidney conditions, fluid overload