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Zhang AJ, Merola JF, Tillett W (2024) Debate at the GRAPPA 2023 Annual Meeting: should methotrexate be the first systemic therapy in psoriatic disease

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Dihydrofolate reductase is a key enzyme in folate metabolism in vivo, responsible for the reduction of dihydrofolate to tetrahydrofolate, which is involved in the methyl shuttle required for the ab initio synthesis of thymidylate and certain amino acids

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