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however, glucagon receptor activation can also increase heart rate and cardiac inotropy, and the net haemodynamic effect of this pathway in humans remains uncertain It is important to emphasise that these mechanistic explanations are working hypotheses

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doi: 10.1097/JCMA.0000000000000443f 140 MeleED'AuriaRScafuroMMarinoMFasanoSViggianoAet al

Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreas