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I had a patient recently who told me a story that perfectly sums up Week 2

Retatrutide Update: UK Mounjaro Price Shock, Lillys AI Deal & PN-477 Rival 21 August 2025 Retatrutide is an investigational weekly injection designed to help with weight management by acting on three hormone receptors at once: GLP-1, GIP and glucagon by a company called Eli Lilly

Its in a class of medicines known as glucagon-like peptide-1 (GLP-1) receptor agonists

By promoting weight loss, particularly visceral adipose tissue reduction, semaglutide decreases the inflammatory burden and free fatty acid release that drive insulin resistance

Even if you thaw the medication, it will likely be ineffective

They bind GHRH receptors on pituitary somatotrophs and directly stimulate GH synthesis and release