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The most common cardiovascular (CV) manifestations in patients with type 2 diabetes are heart failure (HF), stable angina, nonfatal myocardial infarction (MI), peripheral arterial disease and ischemic stroke [2,3,4] which accounts for 60% of their deaths [5]

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There was also a slight increase in the number of foot and toe amputations during the CANVAS trial than is usual so further studies are needed to assess if this is a problem and who is more at risk

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