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A 2025 systematic review found that 35 of 36 BPC-157 studies were conducted in rodents, and the single human study was a small, uncontrolled retrospective analysis of 12 individuals

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The absence of biliary obstruction despite cholestatic liver dysfunction, along with the temporal association with tirzepatide use, helped distinguish this presentation from primary biliary or malignant processes

However, the behaviors were weaker among GLP-1 users