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Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: A 12-week, randomized, double-blind, placebo-controlled study to evaluate different dose-escalation regimens

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First, it acts as a stabilizer for the semaglutide molecule itself, helping maintain peptide integrity in solution

Oral versus injectable semaglutide Oral semaglutide (Rybelsus) has lower bioavailability than injectable forms, meaning more of the drug is lost to first-pass metabolism in the gut and liver

Some patients find Saxendas daily dosing more intuitive, and others appreciate that it produces less intense gastrointestinal effects during titration