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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Sun C., Li T., Song X., Huang L., Zang Q., Xu J., Bi N., Jiao G., Hao Y., Chen Y., et al
While circulating GSH has been proposed to play important systemic roles (1), GSH is distributed across virtually all tissues and cell types (12)
Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function
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