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Nonetheless, overall SCFA depletion (as seen with low-fiber diets or dysbiosis) is generally associated with worse outcomes in aging and neurodegeneration due to loss of their beneficial gut and brain effects

A few practical considerations matter here

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Vitamin B12 is essential for: Converting food into energy Supporting brain and nerve function Producing red blood cells Regulating mood and memory Detoxification and DNA repair While its found in animal-based foods, many people have low levels especially those who are vegan or vegetarian, over age 50, take antacids or metformin, or have gut issues like IBS or IBD

That means they can be more sensitive to substances compared to adults