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These factors collectively establish a robust defensive barrier that significantly compromises treatment efficacy and shelters tumor cells

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OConnor DB, Ferguson E, Green JA, OCarroll RE, OConnor RC

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[1] The Rome IV Diagnostic Criteria (a system developed to classify the functional gastrointestinal disorders) for chronic constipation, states that these symptoms must be present for six months or greater, and must accompany at least 25 percent of bowel movements in the last three months

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