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Treatment is limited to a maximum of 2 years and must be discontinued if adequate weight loss is not achieved within specified timeframes

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This suggests that receptor activation contributes independent benefits beyond calorie reduction

Given the high cost of current GLP-1 receptor agonists, some individuals might find it unaffordable to sustain long-term obesity treatment

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Jeek et al., Glucagon-like peptide-1 receptor is expressed in human and rodent testis