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Weight Loss and Metabolic Factors Behind Blood Pressure Changes A significant portion of blood pressure reduction with GLP-1 therapy occurs through weight loss and accompanying improvements in insulin sensitivity and lipid profiles

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While results from IV ALA studies are consistently positive, the picture is more mixed when it comes to oral-only supplementation: A four-year randomized trial found no significant improvement in a composite measure of nerve function with 600mg/day of oral ALA compared to placebo