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There are other problems associated with traditional antibiotic discovery methods, including the search for amplification of known chemical scaffolds, low access to new chemical varieties, and essentially a focus on individual bacterial cells, which may not be effective concerning the bacterial preference of forming colonies and even biofilms with different bacterial species [56]

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Intravascular contrast media and the blood-brain barrier

1.1 Principles of therapeutic drug monitoring TDM is a clinical conduct to measure the drug concentration in biological samples periodically to adjust the drug dosages to individualize the treatment