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In the SUSTAIN-6 trial, semaglutide was associated with a significant increased risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or conditions requiring treatment with an intravitreal agent or photocoagulation (HR 1.76, 95% CI 1.112.78) [27]

For semaglutide specifically, treatment should be discontinued at least 2 months before a planned pregnancy

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Insulin Resistance and Alzheimer-Like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

Analyses focused on specificity, positive outcome controls, and designated negative outcome controls were performed (Supplementary appendix)