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The condition certainly gets worse in colder weather when the skin is liable to dry out and when the humidity is lower

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Gastroenterology 106:789, 1994 Veljaca M, Lech CA, Pllana R, Sanchez B, Chan K, Guglietta A: BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats

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This advanced formula features targeted probiotic strains including Akkermansia muciniphila and Clostridium butyricum , organisms associated with gut barrier integrity, short-chain fatty acid production, and healthy microbiome diversity