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*JAMA*, 300(18), 2123-2133

doi: 10.1186/1742-2094-10-61 43

296 Despite positive results from early clinical trials, supportive preclinical research, and strong biological plausibility for benefit, the totality of the clinical evidence available as of late 2021 suggests that CoQ10 supplementation may not provide as much benefit on the progression of Parkinsons disease as previously hoped

To explore the role of PPARa in regulating FSP1 in vivo, we established PPARa over-expression and knockdown models in mice by intraspinal injection of lentivirus (Fig S3b, c)