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Glutathione is synthesized in cells by the consecutive reactions of the enzymes -Glutamyl-cysteine (Glu-Cys) synthetase which uses glutamate and cysteine as substrates to generate Glu-Cys

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Other major contributors include lack of sleep, poor diet, and buildup of dead skin cells, all of which make the skin appear uneven and lifeless

demonstrated that IAV infection induces mtROS generation, thereby causing innate immune inflammation and exacerbating viral pathogenesis in a mouse model 137