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This delay allows you to feel fuller longer, which supports weight loss, but it also alters the timing and consistency of bowel movements

Rehackova L, Arajo-Soares V, Adamson AJ, Steven S, Taylor R, Sniehotta FF (2017) Acceptability of a very-low-energy diet in type 2 diabetes: patient experiences and behaviour regulation

Feng X-H, Liu X-M, Zhou L-H, Wang J, Liu G-D

Some individuals maintain results with breaks if they've established exceptional lifestyle habits, but this success rate remains below 20% across all weight categories

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In the 52-week SURPASS-4 trial TZP was tested versus insulin glargine in diabetic adults and a high CV risk below not sufficient GC at baseline and in therapy with one to three oral glucose-lowering drugs (metformin, sulfonylurea, SGLT2-i)